Leica THUNDER CryoCLEM

CryoCLEM combines the advantages of light microscopy, which provides information on the localization of specific structures, with the high resolution of cryoelectron microscopy, which offers detailed information on the ultrastructural details of the sample. This technique is crucial for monitoring and mapping subcellular structures in their physiological environment and allows researchers to study cellular processes and interactions in detail at the molecular level.The THUNDER 5 CryoCLEM is a widefield microscope with a dedicated stage and equipment for these applications with the great advantage of high resolution using the computational clearing method. The system is unique in its features and especially in maintaining cryoteplot for long term monitoring.